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According to the recent increase of NSAID-uses, the possibility of the occurrence of the drug interaction became increased. So we surveyed the drug interaction of NSAIDS in order to inhibit NSAID-related side dffect. This study was accomplished for the NSAID-administered inpatients in Chonnam University Hospital at one day from Jan. to June in 1991. The NSAID-administered in patients occupied 20.2％ of total 3598 drug-administered inpatients. On clinical department, orthopedic surgery occupied the highest value of 15.1％ of NSAID-administered patient. On the route of NSAID administration, injection occupied 32.7％, internal medicine 61.2%, external medicine 0.3％ and the combination of injection of injection & internal medicine 5.8％. On NSAID dosage form, injection occupied 38.5％, internal medicine 67％ and external medicine 0.3％. On the number of used NSAID, one occupied 89.8％, two 9.2％ and three 1%. The average number of NSAID used by a patient was 1.1. The possible occurrence rate of drug interaction of NSAIDS was 33.1％. As the number of used drug increased, the occurrence possibility of drug interaction of NSAIDS tended to increase. The possible occurrence rate of drug interaction of NSAIDS reached 100％ in above 21 drug-used cases. The harmful interaction of NSAIDS could occur such as digitalis toxicity with digoxin in 3 cases. hypoglycemia with antidiabetics in 8 cases, nephrotoxicity with diuretics in 57 cases, hemorrhage with anticoagulants or thrombolytics in 57 cases, gastrointestinal hemorrhage with NSAIDS in 63 cases, the decrease of antihypertensive effect with antihypertensives in 104 cases and the decrease of anti-inflammatory effect with antacids in 135 cases. So we should carefully monitor the drug interaction of NSAIDS and provide drug information to health team in order to prevent the harmful interaction of NSAIDS.
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